actin binding

By Targets:	Arp2/3 Complex (2) Antibiotic (1) Fluorescent Dye (1) Fungal (1) YAP (1)
By Research Areas:	Infection (2) Inflammation/Immunology (1) Neurological Disease (1)

Targets Recommended: Penicillin-binding protein (PBP) Arp2/3 Complex FKBP FABP Transthyretin (TTR) Ligands for Target Protein for PROTAC YB-1 P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2463

Fequesetide	Arp2/3 Complex	Inflammation/Immunology
Fequesetide, a peptide segment, is the active site within the protein thymosin β₄ responsible for actin binding, cell migration and wound healing .

HY-16928

Cytochalasin B 20+ Cited Publications Phomin
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of *actin* filaments, disrupting the formation of actin polymers, with K_d value of 1.4-2.2 nM for F-actin. Cytochalasin B blocks cell migration.

HY-N6682

Cytochalasin D 35+ Cited Publications Zygosporin A; NSC 209835	Arp2/3 Complex Antibiotic YAP	Infection
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-111009

Swinholide A	Fungal	Infection
Swinholide A is the *actin*-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

Cat. No.	Product Name	Target	Research Area

HY-P2463

Fequesetide	Arp2/3 Complex	Inflammation/Immunology
Fequesetide, a peptide segment, is the active site within the protein thymosin β₄ responsible for actin binding, cell migration and wound healing .

HY-P3828

Biotin-myelin basic protein (94-102)	Fluorescent Dye	Neurological Disease
Biotin-myelin basic protein (94-102) is a peptide fragemt. Myelin basic protein is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin, it plays an important role in the process of myelination of nerves in the nervous system. Myelin basic protein also acts as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6682

Cytochalasin D 35+ Cited Publications Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-111009

Swinholide A	Infection Structural Classification Natural Products Classification of Application Fields Animals Source classification Marine natural products Sponge Disease Research Fields	Fungal
Swinholide A is the *actin*-binding marine polyketide and dimerizes actin with the K_d of ~ 50 nM . Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments. Swinholide A disrupts the actin cytoskeleton of cells.Antifungal activity .

Species:	Human (5)
Tag:	His (3) Tag Free (2) Strep (1)
Source:	Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P76470

	KLHL2 Protein, Human (His) Kelch-like protein 2; actin-binding protein Mayven; KLHL2	Human	E. coli
	KLHL2 is a substrate-specific linker in the BCR E3 ubiquitin ligase complex that directs ubiquitination and proteasomal degradation of targets such as NPTXR, WNK1, WNK3, and WNK4. KLHL2 is critical for cellular homeostasis and catalyzes NPTXR ubiquitination, emphasizing its role in targeted protein turnover. KLHL2 Protein, Human (His) is the recombinant human-derived KLHL2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of KLHL2 Protein, Human (His) is 306 a.a., with molecular weight of ~63 KDa.

HY-P701570

	IPP Protein, Human (Sf9) IPP; actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; Kelch-like protein 27	Human	Sf9 insect cells
	IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (Sf9) is the recombinant human-derived IPP protein, expressed by Sf9 insect cells , with tag free. The total length of IPP Protein, Human (Sf9) is 583 a.a., .

HY-P701571

	IPP Protein, Human (Sf9, His, Strep) IPP; actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; Kelch-like protein 27	Human	Sf9 insect cells
	IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (Sf9, His, Strep) is the recombinant human-derived IPP protein, expressed by Sf9 insect cells , with N-Strep, N-8*His labeled tag. The total length of IPP Protein, Human (Sf9, His, Strep) is 583 a.a., .

HY-P701528

	HLTF Protein, Human HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free. The total length of HLTF Protein, Human is 117 a.a., .

HY-P701529

	HLTF Protein, Human (His) HLTF; Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag. The total length of HLTF Protein, Human (His) is 117 a.a., .


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Cat. No.	Product Name	Application	Reactivity

HY-P82158

Sarcomeric alpha Actinin Antibody (YA1903)

actin binding protein; actinin alpha 2; ACTN2; Alpha actinin 2; CMD1AA
WB, IHC-P, IP Human, Mouse, Rat
HY-P82497

GCDFP 15 Antibody (YA2242)

BRST2; GCDGP15; gp17; GPIP4; PIP; Prolactin induced protein; SABP; Secretory actin binding protein
WB, ICC/IF, IP Human
HY-P81344

LSP1 Antibody (YA1089)

Lymphocyte-specific protein 1; Protein pp52; 52 kDa phosphoprotein; Lymphocyte-specific antigen WP34; 47 kDa actin-binding protein
IHC-P Human
HY-P81461

TAGLN/Transgelin Antibody (YA1206)

TAGLN; Transgelin; SM22; WS3-10; 22 kDa actin-binding protein; Protein WS3-10; Smooth muscle protein 22-alpha (SM22-alpha)
IHC-P Human

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actin binding

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